The Elders are featured in the musical episode "See Me, Feel Me, Gnomey".
The elders sent The Gnome a chant to rid Townsville of villainy after the Girls agreement to give up their powers in exchange to free Townsville from evil.
Very little is known about the elders. They are very powerful, and they are the gnome's source of power. Supposedly they can control events occurring in Townsville. It's also possible that their reign extends not only Townsville but also to the rest of the world.
It's possible to connect the elders to Hinduism due the four faces representing them. According to Hinduism the world was created by Brahma, the god of creation. Just like Brahma, the elders have four faces.