Pokey Oaks Kindergarten is a solely kindergarten school that the Powerpuff Girls attend in Pokey Oaks North. The only teacher there is Ms. Keane whose teaching ranges from basic Kindergarten skills, to laws of advanced Einstein level physics to her students. The City of Clipsville hints in one of its flashbacks that when the girls speed up time and become Valley Girl-ish teenagers , the school may have evolved into a high school.
The students at Pokey Oaks are often seen coloring, playing with toys, or doing simple math problems and/or sums.
- The Powerpuff Girls
- Mitch Mitchelson - A typical "bad" boy that frequently wears black and is always acting out in class.
- Elmer Sglue - A classmate of the Girls who is constantly made fun of for eating paste. He wears thick glasses (implying he's blind) and a smear of paste around his lips, and he has a very timid voice. He once ate radioactive paste mutating him into a monster.
- Harry Pitt - This boy is always seen playing in soil or doing other miscellaneous things that get him dirty.
- Princess Morbucks
- Mary - An overweight girl with a nasal voice. She has a shy personality and wears a flowered dress. She is voiced by Jennifer Hale.
- Susie Jenkins - A girl, who took a "poisoned" cookie from Blossom (Substitute Creature). She is voiced by Jennifer Hale.
- Julie Bean - A student with curly, orange hair and green dress. She is voiced by Cathy Cavadini.
- Pablo - A boy with ability to speaking Spanish. He is voiced by Dee Bradley Baker and appears in Ice Sore.
- Wes Goingon - Appears in Paste Makes Waste.
- Lloyd & Floyd Floyjoydson - Identical twins that bullied Elmer and are Mitch's friends Appears in Paste Makes Waste.
- Joey - A boy first appearing in Equal Fights. He is voiced by Tara Strong.
- Jeff - Wheel-chair mobile student from Mojo Jonesin'.
- Kim - She wanted to have superpowers and is best known for appearing in Mojo Jonesin'. Voiced by Tara Charendoff Strong.
- Football Kid (voiced by Jeff Bennett).
- Billy (voiced by Tom Kenny)
- Hanout (Ice Sore)
- Kristen (voiced by Julie Nathanson)
- Clara - An African-American girl student with glasses and purple dress.
One - time Students
- Robin Snyder
- Mike Believe : A new student at Pokey Oaks Kindergarten. He appeared in the episode Imaginary Fiend. Voiced by Aaron Spann.
- in the 2016 series, the school is replaced by Midway Elementary School, which is bigger because it does include more grades than just Kindergarten. Ms. Keane still teaches here. However, the episode The Wrinklegruff Gals features Pokey Oaks in a flashback.