|Episode name pun on: Primates|
|Airdate:||April 16, 2004|
"Sweet 'N Sour"
Prime Mates is the first episode of Season 6 and part 1 of episode 66.
Back when Mojo Jojo tried to take over the world with primates, there was one monkey who didn't get his due; Mopey Popo. Now, Mopey is back to try and be evil just as Mojo Jojo intended, if only he could get something right.
- Monkey from Dexter's Laboratory makes an cameo appearance as a doll/plush in Mojo Jojo's bed at the beginning of the episode.
- This episode is the fifth final extra from The Powerpuff Girls Movie.
- Footage from The Powerpuff Girls Movie is shown of Mojo initiating his plan of ruling the world with monkeys, along with new footage animated for this episode.
- This is one of the episodes in which the Narrator says his catchphrase differently: "And so for the only time, the day is saved, thanks to mopey Mopey Popo."
- Mopey's way of talking is based on Droopy, as the voices are similar as well.
- This is the only time in the series where one of Mojo Jojo's supposed "henchmen" from the movie makes an appearance in the show.