In Demashita! Powerpuff Girls Z, the Mayor of Townsville is now the Mayor of Tokyo City (New Townsville in the English dub). His design is distinctly different from his American counterpart, as he is of normal height and has no monocle or top hat. While less extreme in comparison to the Mayor of Townsville, the Mayor of New Townsville is very childish and has a very short attention span. He seems to worry quite a lot when the girls are fighting, and wishes that they could cause a little less damage. The Mayor, like many of the characters in the anime, loves sweets. Like in the episode "Something's a Ms" he has a crush on Miss Bellum as revealed in the final episode and relies on her a lot even admitting he can't do anything without her, unlike his counterpart. The Mayor also has a younger brother, who is the Principal of the school that Momoko, Miyako, and Kaoru attend. It was through him that Miss Bellum and the Mayor were able rearrange the classes, so that the girls would be in the same class. However, the Mayor and the Principal, don't always get along and even the most minor of things will set off an argument between them, which often leads to name calling. He also deals with his brother when the girls aren't doing well in class due to them skipping class to save the city.
- In episode 51 of Demashita! Powerpuff Girls Z, a caveman version of the Mayor that is closer to the original design does make a brief appearance.
- The original design for the Mayor in Demashita! Powerpuff Girls Z, was closer to the original. He was also named "Mayor Mayer"
- The Mayor Was Inspired By Rich Uncle Pennybags From Monopoly.
- Mr. Herriman from Foster's Home For Imaginary Friends has many similarities with the Mayor due to the fact that both of their cartoons were created by Craig McCracken. Both wear a Monocle and black hats. And both crave foods Mr. Herriman (Carrots) The Mayor (Pickles).
- In the same show, the episode "Land of the Flea" features himself as an imaginary flea among other fleas, in a very brief cameo.